2-(cyclopropanecarboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide
AX20017
CAS: 329221-38-7
Molecular Formula: C13H16N2O2S
2-(cyclopropanecarboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide - Names and Identifiers
2-(cyclopropanecarboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide - Physico-chemical Properties
| Molecular Formula | C13H16N2O2S |
| Molar Mass | 264.34 |
| Solubility | DMSO: ≥ 32 mg/mL |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| In vitro study | The compound AX20017 inhibitor is bound deep within a narrow pocket formed by the inter lobe cleft of the PknG domain. The main chain Glu233:O and Val235:NH of PknG form hydrogen bonds with AX20017.AX20017 results in mycobacterial transfer to lysosomes and killing of the mycobacteria. AX20017 does not affect the human kinases, whereas the activity of PknG is effectively inhibited. AX20017 does not affect cellular morphology, membrane ruffling, or macropinocytosis. |
2-(cyclopropanecarboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.783 ml | 18.915 ml | 37.83 ml |
| 5 mM | 0.757 ml | 3.783 ml | 7.566 ml |
| 10 mM | 0.378 ml | 1.891 ml | 3.783 ml |
| 5 mM | 0.076 ml | 0.378 ml | 0.757 ml |
Last Update：2024-01-02 23:10:35
2-(cyclopropanecarboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide - Reference Information
| biological activity | AX20017 is a small molecule inhibitor of protein kinase G (PknG) with an IC50 value of 0.39 μm. |
| Target | IC50: 0.39 μm (PknG) |
Last Update：2024-04-10 22:29:15
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Product Name: AX20017 Visit Supplier Webpage Request for quotationCAS: 329221-38-7
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: AX20017 Visit Supplier Webpage Request for quotationCAS: 329221-38-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: AX20017 Visit Supplier Webpage Request for quotationCAS: 329221-38-7
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: AX20017 Visit Supplier Webpage Request for quotationCAS: 329221-38-7
Tel: 18301782025
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View History
2-(cyclopropanecarboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide
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